Clinical Aspects on Diabetes mellitus during Pregnancy

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Remission of diabetes mellitus during pregnancy.

Two cases are reported in which a remission of diabetes was sustained throughout pregnancy. This seemed to be due in part to improved beta-cell function consequent on restoration of normoglycaemia before pregnancy, and in part to an increase in insulin sensitivity during pregnancy, which in the first case disappeared very rapidly after delivery.

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The introduction of insulin produced a rapid improvement in the maternal prognosis in pregnancy associated with diabetes mellitus. Within years, maternal mortality fell from 50% and has become a rarity. Improvement in fetal survival was less dramatic until the work of Pedersen (1952); Peel and Oakley (1950) and White (1949) demonstrated that with determined antenatal control of diabetes the fet...

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ENDOCRINOLOGY OF PREGNANCY: Gestational diabetes mellitus: definition, aetiological and clinical aspects.

Gestational diabetes (GDM) is defined as a glucose intolerance resulting in hyperglycaemia of variable severity with onset during pregnancy. This review aims to revisit the pathogenesis and aetiology of GDM in order to better understand its clinical presentation and outcomes. During normal pregnancy, insulin sensitivity declines with advancing gestation. These modifications are due to placental...

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Diabetes Mellitus and Pregnancy *

This report is a survey of all pregnancies complicated by diabetes delivered in a general hospital between 1921 and 1943. Omitted from consideration are 3 self-induced abortions and 10 early therapeutic abortions. Of the latter, one was performed because of previous toxemia of pregnancy (case 1, to be described), one because of pre-existent nephritis, one because of emaciation from long neglect...

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Diabetes Mellitus and Pregnancy

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ژورنال

عنوان ژورنال: Juntendo Medical Journal

سال: 1974

ISSN: 0022-6769,2188-2134

DOI: 10.14789/pjmj.20.418